Moving into advanced nanomaterials. Toxicity of rutile TiO₂ nanoparticles immobilized in nanokaolin nanocomposites on HepG2 cell line

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• 作者：Maria Joã ; o Bessa^a ; ^{mjbessa8@gmail.com} ; Carla Costa^a ; ^b ; ^{cstcosta@gmail.com} ; Julian Reinosa^c ; ^{jjreinosa@icv.csic.es} ; Cristiana Pereira^a ; ^b ; ^{cristianacostapereira@gmail.com} ; Só ; nia Fraga^a ; ^b ; ^{teixeirafraga@hotmail.com} ; José ; Fern&aacute ; ndez^c ; ^{jfernandez@icv.csic.es} ; Miguel A. Bañ ; ares^d ; ^{miguel.banares@csic.es} ; Joã ; o Paulo Teixeira^a ; ^b ; ^{jpft12@gmail.com}
• 关键词：Titanium dioxide nanoparticles ; Kaolin nanoclay ; In vitro ; Interferences studies ; Cytotoxicity ; Genotoxicity
• 刊名：Toxicology and Applied Pharmacology
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：316
• 期：Complete
• 页码：114-122
• 全文大小：715 K
• 卷排序：316

文摘

Only the MTT and AB assays were found to be suitable for cytotoxicity assessment. Alkaline comet assay was also appropriate for genotoxicity evaluation. All nanomaterials decreased the HepG2 cell viability and caused DNA damage. Nanokaolin is not a suitable clay substrate for the immobilization of TiO2 NPs. Further toxicity studies must be performed in other clays to support nanoparticles.