Chronic citalopram administration desensitizes prefrontal cortex but not somatodendritic α₂-adrenoceptors in rat brain

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• 作者：Begoñ ; a Fern&aacute ; ndez-Pastor^a ; ¹ ; Jorge E. Ortega^a ; ^b ; ^d ; ^{jorge.ortega@ehu.eus} ; Laura Grandoso^a ; ² ; Elena Castro^b ; ^c ; Luisa Ugedo^a ; &Aacute ; ngel Pazos^b ; ^c ; J. Javier Meana^a ; ^b ; ^d
• 关键词：Microdialysis ; Locus coeruleus ; Prefrontal cortex ; Noradrenaline ; α2-adenoceptor ; Citalopram
• 刊名：Neuropharmacology
• 出版年：2017
• 出版时间：1 March 2017
• 年：2017
• 卷：114
• 期：Complete
• 页码：114-122
• 全文大小：1312 K
• 卷排序：114

文摘

Chronic SSRI citalopram treatment increases NA concentration selectively in PFC. Chronic citalopram does not change somatodendritic α2-adrenoceptor sensitivity. Chronic citalopram induces selective α2-adrenoceptor desensitization in PFC. Reduction of α2-adrenoceptor-coupling to G-proteins is the mechanism involved. Addition of α2-antagonists to SSRIs could increase antidepressant response.