Have many estimates of efficacy and affinity been misled? Revisiting the operational model of agonism
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- 作者：David Roche1 ; Piet H. van der Graaf2 ; 3 ; Jesú ; s Giraldo1 ; Jesus.Giraldo@uab.es" class="auth_mail" title="E-mail the corresponding author
- 刊名：Drug Discovery Today
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：21
- 期：11
- 页码：1735-1739
- 全文大小：522 K
文摘
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The operational model with the slope parameter equal to 1 is a Hill equation.
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The operational model with the slope parameter different from 1 is not a Hill equation.
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Fitting the operational model to steep or flat Hill curves could yield misled parameter estimates.
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A new operational model is proposed to fit steep or flat Hill curves.