Activation of HIPK2 Promotes ER Stress-Mediated Neurodegeneration in Amyotrophic Lateral Sclerosis

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• 作者：Sebum Lee¹ ; Yulei Shang¹ ; Stephanie A. Redmond² ; ³ ; Anatoly Urisman¹ ; Amy A. Tang¹ ; Kathy H. Li⁴ ; Alma L. Burlingame⁴ ; Ryan A. Pak¹ ; Ana Jovičić⁵ ; Aaron D. Gitler⁵ ; Jinhua Wang⁶ ; Nathanael S. Gray⁶ ; William W. Seeley¹ ; ² ; Teepu Siddique⁷ ; Eileen H. Bigio⁸ ; Virginia M.-Y. Lee⁹ ; John Q. Trojanowski⁹ ; Jonah R. Chan² ; ³ ; Eric J. Huang¹ ; ² ; ³ ; ¹⁰ ; ^{eric.huang2@ucsf.edu" class="auth_mail" title="E-mail the corresponding author}
• 刊名：Neuron
• 出版年：2016
• 出版时间：6 July 2016
• 年：2016
• 卷：91
• 期：1
• 页码：41-55
• 全文大小：6078 K

文摘

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d="p0010">ER stress activates epitope-specific phosphorylation of HIPK2 to promote cell death

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d="p0015">Loss of HIPK2 mitigates neurodegeneration and improves survival in SOD1^G93A mice

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d="p0020">TDP-43 proteinopathy positively correlates with HIPK2-JNK activation in ALS

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d="p0025">HIPK2 inhibitors protect neurons from toxicity by SOD1^G93A and TDP-43 proteinopathy

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