Disturbances of vasoactive mediators, hormonal and electrolyte imbalance were obvious in scorpion envenomed children. The complication was obvious in children below 5 years old. The magnitude of elevation/decline of these biomarkers was directly related to the occurrence of complication. Profiling these biomarkers could be considered for evaluation in scorpion envenomed children. The use of inhibitors of these vasoactive biomarkers should be considered as a line of treatment.