Combinatorial synthesis, in silico, molecular and biochemical studies of tetrazole-derived organic selenides with increased selectivity against hepatocellular carcinoma
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- 作者：Saad Shaabana ; e ; dr_saad_chem@mans.edu.eg" class="auth_mail" title="E-mail the corresponding author ; Amr Negmb ; Abeer M. Ashmawyc ; Dalia M. Ahmedd ; Ludger A. Wessjohanne ; wessjohann@ipb-halle.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Organoselenium ; Diselenides ; Quinone ; Tetrazole ; Azido-Ugi reaction ; Redox modulators ; Caspase-8 ; Apoptosis ; Ki-67 ; Bcl-2
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2016
- 出版时间：21 October 2016
- 年：2016
- 卷：122
- 期：Complete
- 页码：55-71
- 全文大小：1876 K
文摘
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A series of tetrazole-based diselenides and selenoquinones were synthesized.
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Most of the compounds were selectively more cytotoxic to HepG2 cells.
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Some compounds showed good free radical scavenging activity in the DPPH assay.
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Compounds 9, 12, 14, 19 and 21 manifested good GPx catalytic activity.
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Compounds 18, 21, 22 and 23 modulated the levels of caspase-8, Bcl-2 and Ki-67.