Fatty Acid Oxidation-Driven Src Links Mitochondrial Energy Reprogramming and Oncogenic Properties in Triple-Negative Breast Cancer
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- 作者：Jun Hyoung Park1 ; Sajna Vithayathil1 ; Santosh Kumar1 ; Pi-Lin Sung1 ; 2 ; Lacey Elizabeth Dobrolecki3 ; Vasanta Putluri4 ; Vadiraja B. Bhat5 ; Salil Kumar Bhowmik4 ; Vineet Gupta1 ; Kavisha Arora1 ; Danli Wu6 ; Efrosini Tsouko7 ; Yiqun Zhang8 ; Suman Maity4 ; Taraka R. Donti1 ; Brett H. Graham1 ; Daniel E. Frigo7 ; 9 ; Cristian Coarfa4 ; Patricia Yotnda6 ; Nagireddy Putluri4 ; Arun Sreekumar4 ; 8 ; Michael T. Lewis3 ; 4 ; Chad J. Creighton8 ; Lee-Jun C. Wong1 ; ljwong@bcm.edu" class="auth_mail" title="E-mail the corresponding author ; Benny Abraham Kaipparettu1 ; 8 ; kaippare@bcm.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：8 March 2016
- 年：2016
- 卷：14
- 期：9
- 页码：2154-2165
- 全文大小：5003 K
文摘
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Metastatic TNBC is dependent on mitochondrial FAO energy metabolism
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FAO activates c-Src via autophosphorylation at residue Y419
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CPT genes are critical in TNBC tumor progression and metastasis
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Reduction of fat or FAO may provide clinical benefit to TNBC patients