Histone deacetylase 6 negatively regulates NLRP3 inflammasome activation
详细信息 查看全文
- 作者：Inhwa Hwang ; Eunju Lee ; Seon-A Jeon ; Je-Wook Yu ; jewookyu@yuhs.ac" class="auth_mail" title="E-mail the corresponding author
- 关键词：Histone deacetylase 6 ; NLRP3 ; Inflammasome
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2015
- 出版时间：27 November 2015
- 年：2015
- 卷：467
- 期：4
- 页码：973-978
- 全文大小：1122 K
文摘
- •
Knockdown of HDAC6 potentiates the activation of NLRP3 inflammasome.
- •
HDAC6 deficiency does not affect the transcriptional level of NLRP3.
- •
Deacetylase activity of HDAC6 is not related to the increased NLRP3 activation.
- •
HDAC6 interacts with NLRP3 through its ubiquitin-binding domain.