High prevalence of tenosynovial inflammation before onset of rheumatoid arthritis and its link to progression to RA—A combined MRI/CT study

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• 作者：Arnd Kleyer^a ; ¹ ; Manuel Krieter^a ; ¹ ; Isabelle Oliveira^a ; Francesca Faustini^a ; David Simon^a ; Nadine Kaemmerer^b ; Alan Cavalcante^c ; Taiane Tabosa^c ; Juergen Rech^a ; Axel Hueber^a ; Georg Schett^a ; ^{georg.schett@uk-erlangen.de" class="auth_mail" title="E-mail the corresponding author}
• 关键词：ACPA ; pre-RA ; Tenosynovitis ; Imaging ; MRI ; CT
• 刊名：Seminars in Arthritis and Rheumatism
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：46
• 期：2
• 页码：143-150
• 全文大小：1810 K

文摘

To define the anatomic distribution of the earliest inflammatory and structural changes in individuals with anti-citrullinated protein antibody (ACPA+) positivity but no signs of arthritis.

Methods

ACPA+ individuals (N = 20) and healthy controls (N = 13) received simultaneous gadolinium-enhanced magnetic resonance imaging (MRI) and high-resolution peripheral quantitative computed tomography (HR-pQCT) of the hands. MRI sequences were scored for synovitis, osteitis, and bone erosions according to the RAMRIS method as well as for presence, localization, and extent of tenosynovitis. Bone erosions were validated by HR-pQCT scanning and related to the inflammatory changes found in the MRI.

Results

Tenosynovitis was the most prevalent inflammatory pathology, affecting 80% of ACPA+ individuals but none of the controls. Tenosynovitis at two or more anatomical sites was associated with later development of RA. Synovitis (65%) and osteitis (35%) were present in ACPA+ individuals as well, but at a lower frequency than tenosynovitis. MRI bone erosions were found in 65% of the individuals and additionally confirmed by HR-pQCT. Presence of MRI osteitis was the inflammatory pathology most strongly associated with bone erosions.

Conclusion

Tenosynovitis is highly prevalent in ACPA+ individuals without arthritis and associated with later development of RA. Small erosions, often linked to osteitis, are also found in ACPA+ individuals without arthritis.