Rheumatoid arthritis onset in postmenopausal women: Does the ACPA seropositive subset result from genetic effects, estrogen deficiency, skewed profile of CD4+ T-cells, and their interactions?
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- 作者：Rony Sapir-Korena ; Gregory Livshitsa ; b ; gregl@post.tau.ac.il" class="auth_mail" title="E-mail the corresponding author
- 关键词：Estrogens ; HLA-DRB1 SE ; ACPA ; Cytokines ; Gene-environment interactions ; Smoking
- 刊名：Molecular and Cellular Endocrinology
- 出版年：2016
- 出版时间：15 August 2016
- 年：2016
- 卷：431
- 期：Complete
- 页码：145-163
- 全文大小：1029 K
文摘
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Genetic risk alleles that interact with estrogenic factors underlie women’s RA susceptibility.
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Infectious agents and smoking add complexity to this gene-estrogen interaction.
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The biological mechanisms leading to RA may differ between pre- and post-menopausal women.
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Postmenopausal RA is hypothesized to be characterized by seropositivity for ACPA.
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Postmenopausal ACPA(+) RA results of skewed CD4+ T cell profile and derived cytokines.