Hantavirus infection-induced thrombocytopenia triggers increased production but associates with impaired aggregation of platelets except for collagen
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- 作者：Outi Lainea ; b ; outi.laine@staff.uta.fi" class="auth_mail" title="E-mail the corresponding author ; Lotta Joutsi-Korhonenc ; lotta.joutsi-korhonen@hus.fi" class="auth_mail" title="E-mail the corresponding author ; Riitta Lassilad ; riitta.lassila@hus.fi" class="auth_mail" title="E-mail the corresponding author ; Tomi Koskie ; tomi.koski@fimlab.fi" class="auth_mail" title="E-mail the corresponding author ; Heini Huhtalaf ; heini.huhtala@uta.fi" class="auth_mail" title="E-mail the corresponding author ; Antti Vaherig ; antti.vaheri@helsinki.fi" class="auth_mail" title="E-mail the corresponding author ; Satu Mä ; kelä ; a ; satu.marjo.makela@uta.fi" class="auth_mail" title="E-mail the corresponding author ; Jukka Mustonena ; b ; jukka.mustonen@uta.fi" class="auth_mail" title="E-mail the corresponding author
- 关键词：HCPS ; hantavirus cardiopulmonary syndrome ; PUUV ; Puumala virus ; NE ; nephropathia epidemica ; AKI ; acute kidney injury ; ADAMTS13 ; a thrombospondin type 1 domain 13 ; PAI-1 ; plasminogen activator inhibitor 1 ; HTNV ; Hantaan virus ; MPV ; mean platelet volume ; IPF% ; immature platelet fraction ; PFA-100 ; platelet function analyzer 100 ; CRP ; C-reactive protein ; ADP ; adenosine diphosphate ; ARA ; arachinodic acid ; COLL ; collagen ; TRAP ; thrombin receptor activating peptide ; RISTO ; ristocetin ; ADR ; adrenalin ; P
- 刊名：Thrombosis Research
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：136
- 期：6
- 页码：1126-1132
- 全文大小：367 K
文摘
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Thrombocytopenia during acute hantavirus disease was studied in 31 patients.
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Mean platelet volume and immature platelet fraction were high.
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Multiplate® found decreased platelet aggregation responses especially to thrombin.
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Aggregation responses to collagen were the least attenuated.
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Platelet adhesive mechanisms on collagen studied with PFA-100® were intact.