Membrane lipid peroxidation in neurodegeneration: Role of thrombin and proteinase-activated receptor-1
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- 作者：Bruce A. Citrona ; b ; 1 ; Syed Ameenuddina ; 2 ; K. Uchidaf ; William Z. Suoa ; b ; Karen SantaCruza ; d ; 3 ; Barry W. Festoffa ; b ; c ; e ; bwfestoff@mac.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Membrane lipid peroxidation ; Reactive oxygen ; Apoptosis ; Neurodegenerative diseases ; Spinal cord injury
- 刊名：Brain Research
- 出版年：2016
- 出版时间：15 July 2016
- 年：2016
- 卷：1643
- 期：Complete
- 页码：10-17
- 全文大小：1041 K
文摘
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Proteins from human AD and PD brains exhibit significant lipid peroxidation.
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Acrolein and 4-hydroxynonenal adducts were found in neurodegenerative proteins.
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Lipid peroxidation in cultured model neurons can be induced by exposure to thrombin.
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Proteinase activated receptor activating peptide causes similar lipid peroxidation.
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The expression of proteinase activated receptor 1 is also upregulated by thrombin.