Tetraethylorthosilicate as a mild dehydrating reagent for the synthesis of N-formamides with formic acid

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• 作者：Yasuhiro Nishikawa ; ^{yasuhiro@meijo-u.ac.jp} ; Hidetsugu Nakamura ; Norimitsu Ukai ; Wakana Adachi ; Osamu Hara ; ^{oshara@meijo-u.ac.jp}
• 关键词：Formylation ; Silicate ; Dehydration ; Amino acids ; Amide bond
• 刊名：Tetrahedron Letters
• 出版年：2017
• 出版时间：1 March 2017
• 年：2017
• 卷：58
• 期：9
• 页码：860-863
• 全文大小：746 K
• 卷排序：58

文摘

N-Formylation with formic acid and Si(OEt)4 under mild conditions was achieved. Si(OEt)4 is inexpensive and environmentally benign dehydrating reagent. A variety of amines including amino acid derivatives can be applied to this method.