The role of hepatocyte nuclear factor 4-alpha in perfluorooctanoic acid- and perfluorooctanesulfonic acid-induced hepatocellular dysfunction
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- 作者：Kevin M. Beggsa ; kbeggs2@kumc.edu" class="auth_mail" title="E-mail the corresponding author ; Steven R. McGreala ; smcgreal@kumc.edu" class="auth_mail" title="E-mail the corresponding author ; Alex McCarthya ; Sumedha Gunewardenab ; sgunewardena@kumc.edu" class="auth_mail" title="E-mail the corresponding author ; Jed N. Lampea ; jlampe@kumc.edu" class="auth_mail" title="E-mail the corresponding author ; Christoper Lauc ; lau.christopher@epa.gov" class="auth_mail" title="E-mail the corresponding author ; Udayan Aptea ; uapte@kumc.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：ADH1B ; alcohol dehydrogenase 1B ; AKR1B10 ; aldo-keto reductase 1B10 ; ALT ; alanine aminotransferase ; CCND1 ; cyclin D1 ; CLDN1 ; claudin 1 ; CYP7A1 ; cytochrome P450 7A1 ; DMSO ; dimethyl sulfoxide ; GAPDH ; glyceraldehyde 3-phosphate dehydrogenase ; HNF4α ; hepatocyte nuclear factor 4-alpha ; IPA ; Ingenuity Pathway Analysis ; PFOA ; perfluorooctanoic acid ; PFOS ; perfluorooctanesulfonic acid ; PLIN2 ; perilipin 2 ; PPAR ; peroxisome proliferator-activated receptor ; TAT ; tyrosine aminotransferase
- 刊名：Toxicology and Applied Pharmacology
- 出版年：2016
- 出版时间：1 August 2016
- 年：2016
- 卷：304
- 期：Complete
- 页码：18-29
- 全文大小：1287 K
文摘
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PFOA and PFOS cause decreased HNF4α protein expression in human hepatocytes.
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PFOA and PFOS promote changes associated with lipid metabolism and carcinogenesis.
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PFOA and PFOS induced changes in gene expression associated with cellular dedifferentiation.
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PFOA and PFOS induce expression of Nanog, a transcription factor involved in stem cell development.