4-Aminoantipyrine reduces toxic and genotoxic effects of doxorubicin, cisplatin, and cyclophosphamide in male mice
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- 作者：Claudia Rodrigues Bernoa ; b ; Barbara de Toledo Ró ; sa ; b ; Ingridhy Ostaciana Maia Freitas da Silveirac ; Henrique Rodrigues Coelhod ; André ; ia Conceiç ; ã ; o Milan Brochado Antoniollia ; d ; Adilson Beatrizb ; c ; Dê ; nis Pires de Limab ; c ; Antô ; nio Carlos Duenhas Monrealb ; Fabricio Garmus Sousab ; Roberto da Silva Gomesc ; e ; Rodrigo Juliano Oliveiraa ; b ; d ; rodrigo.oliveira@ufms.br" class="auth_mail" title="E-mail the corresponding author
- 关键词：4-aminoantipyrine ; dipyrone ; cancer ; DNA damage ; immunomodulatory effect
- 刊名：Mutation Research/Genetic Toxicology and Environmental Mutagenesis
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：805
- 期：Complete
- 页码：19-24
- 全文大小：1538 K
文摘
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4-aminoantipyrine (4-AA) is not genotoxic and mutagenic in vivo.
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4-AA can interfere with DNA damaging agents biological activities.
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4-AA may reduce the effectiveness of DNA damage-based chemotherapy.