Synthesis, solution and crystal structure of the coenzyme B12 analogue Coβ-2‿fluoro-2‿5‿dideoxyadenosylcobalamin
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- 作者：Miriam Hungera ; Klaus Wurstb ; Bernhard Krä ; utlera ; Bernhard.kraeutler@uibk.ac.at" class="auth_mail" title="E-mail the corresponding author
- 关键词：Electrosynthesis ; Fluorine label ; NMR ; H-bonds ; Vitamin B12 ; X-ray structure
- 刊名：Journal of Inorganic Biochemistry
- 出版年：2015
- 出版时间：July 2015
- 年：2015
- 卷：148
- 期：Complete
- 页码：62-68
- 全文大小：778 K
文摘
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Synthesis of Coβ-2′-fluoro-2′,5′-dideoxyadenosylcobalamin, lacking the critical 2′-OH group
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Solution structure of 2′FAdoCbl has similar features as that of coenzyme B12 (AdoCbl).
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Crystal structure of 2′FAdoCbl is similar to the structure of AdoCbl in the crystal.
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First coenzyme B12 analogue with 19F-label in the organometallic moiety for 19F NMR