刊名:Biochemical and Biophysical Research Communications
出版年:2017
出版时间:12 February 2017
年:2017
卷:483
期:3
页码:941-945
全文大小:821 K
卷排序:483
文摘
Cell treatment with PTX results in destabilization of Gαi but not Gαq. PTX fails to destabilize a mutant Gαi2 that does not undergo ADP-ribosylation. Gαi is stabilized by a specific effect of endogenous and exogenous Ric-8A. Ric-8A neither interacts with nor efficiently stabilizes ADP-ribosylated Gαi.