The role of serotonergic, adrenergic and dopaminergic receptors in antidepressant-like effect

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• 作者：Karolina Pytka^a ; ^{karolina.pytka@uj.edu.pl" class="auth_mail" title="E-mail the corresponding author} ; Karolina Podkowa^b ; Anna Rapacz^a ; Adrian Podkowa^a ; Elżbieta Żmudzka^a ; Adrian Olczyk^c ; Jacek Sapa^a ; Barbara Filipek^a
• 关键词：Serotonergic receptors ; Adrenergic receptors ; Dopaminergic receptors ; Antidepressant-like effect
• 刊名：Pharmacological Reports
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：68
• 期：2
• 页码：263-274
• 全文大小：778 K

文摘

Depression is a serious global illness, becoming more and more common in developed countries. Because of specific symptoms it is considered as a leading cause of disability all over the world with a high death factor due to suicides. There are many antidepressants used in the therapy, but still more than 30% of patients do not respond to the treatment. The heterogeneous nature of the illness and its complex, unclear aetiology may be responsible for these difficulties. Next to the main monoaminergic hypothesis of depression there are also many other approaches connected with the pathophysiology of the disease, including hypothalamic–pituitary–adrenal axis dysregulation, dopaminergic, cholinergic, glutamatergic or GABA-ergic neurotransmission. Nevertheless, it can be unambiguously stated that serotonergic, noradrenergic and dopaminergic systems are precisely connected with pathogenesis of depression, and should be therefore considered as valuable targets in patients’ treatment. Bearing that in mind, this review presents the role of serotonergic, adrenergic and dopaminergic receptors in antidepressant-like effect.