Convergent phosphomodulation of the major neuronal dendritic potassium channel Kv4.2 by pituitary adenylate cyclase-activating polypeptide
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- 作者：Raeesa P. Guptea ; b ; c ; Suraj Kadunganattilb ; c ; 1 ; Andrew J. Shepherda ; b ; c ; 1 ; Ronald Merrilla ; 1 ; William Planerb ; Michael R. Bruchasb ; Stefan Stracka ; Durga P. Mohapatraa ; b ; c ; d ; mohapatrad@anest.wustl.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Pituitary adenylate cyclase-activating peptide (PACAP) ; G protein-coupled receptor (GPCR) ; Extracellular-signal-regulated kinase (ERK) ; Protein kinase A (PKA) ; Potassium channel ; Kv4.2 ; Ion channel modulation
- 刊名：Neuropharmacology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：101
- 期：Complete
- 页码：291-308
- 全文大小：4629 K
文摘
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PACAP activation of hippocampal PAC1 isoforms leads to PKA and ERK1/2 activation.
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The major dendritic K+ channel Kv4.2 is dynamically downregulated by PAC1/PKA/ERK1/2 signaling.
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Convergence of PKA and ERK1/2, and phosphorylation of Kv4.2 by the later reduces channel density.
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PACAP modulation of Kv4.2 is not influenced by voltage-dependence of channel activation.