P0093 MicroRNA-497 inhibits the invasion and metastasis of colorectal cancer by targeting vascular endothelial growth factor-A

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• 作者：Y.-Y. Qiu ; P.-H. Yin
• 刊名：European Journal of Cancer
• 出版年：2015
• 出版时间：July 2015
• 年：2015
• 卷：51
• 期：supp_S2
• 页码：e18
• 全文大小：33 K

文摘

MicroRNAs (miRNAs), which are non-coding RNAs that regulate gene expression, are involved in tumour metastasis. In this study, we describe the downregulation and function of miR-497 in colorectal cancer (CRC) metastasis.

Methods

We compared expression of miR-497 in CRC tissues and corresponding tissues without tumours.

Findings

MiR-497 was underexpressed in 34 CRC tissues compared with their corresponding tissues without tumours and in the HCT8, LOVO, Ls-174, HCT116, and HT29 cell lines. Overexpression of miR-497 did not inhibit CRC cell growth but suppressed CRC cell metastasis and invasion in vitro and in vivo. MiR-497 might suppress invasion and metastasis of CRC cells by targeting VEGF-A. We also found that overexpression of miR-497 altered the expression of key components in the VEGF-A/ERK/MMP-9 signalling pathway.

Interpretation

miR-497 can function as an inhibitory factor in the metastasis of CRC, demonstrating the potential of this molecule as a promising novel therapeutic target. This study also revealed that the miR-497/VEGF-A/ERK/MMP-9 signalling pathway is involved in the metastasis of CRC.