Assessment of the proliferative capacity of the flavanones 8-prenylnaringenin, 6-(1.1-dimethylallyl)naringenin and naringenin in MCF-7 cells and the rat mammary gland
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- 作者：Janina Hellea ; Janina.Helle@tu-dresden.de" class="auth_mail ; Kristin Krä ; kera ; Manuela I. Badera ; Annekathrin M. Keilera ; Oliver Zieraua ; Gü ; nter Vollmera ; JoEllen Welshb ; Georg Kretzschmara
- 关键词：8-PN ; 8-Prenylnaringenin ; 6-DMAN ; 6-(1.1-dimethylallyl)naringenin ; Nar ; naringenin ; E2 ; 17尾-Estradiol ; ER ; estrogen receptor ; TEB ; terminal end bud ; HRT ; hormone replacement therapy ; IGF-1 ; insulin-like growth factor ; FGF ; fibroblast derived growth factor ; EGF ; epidermal growth factor ; TGF-尾 ; transforming growth factor 尾 ; aERKO ; estrogen receptor 伪 knock out ; bERKO ; estrogen receptor 尾 knock out ; PGR ; progesterone receptor ; PRKO ; progesterone receptor knock out ; CEE ; conjugated equine estrogen
- 刊名：Molecular and Cellular Endocrinology
- 出版年：5 July 2014
- 年：2014
- 卷：392
- 期：1-2
- 页码：125-135
- 全文大小：2172 K
文摘
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Naringenin type phytoestrogens bind ER subtypes with different affinities.
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8-PN, 6-DMAN and Nar induce mitotic effects in MCF-7 cells.
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8-PN and 6-DMAN treatment display proliferative effects on the mammary gland of rats.
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Proliferative responses in the mammary gland are weak compared to E2 treatment.