Muscle FBPase binds to cardiomyocyte mitochondria under glycogen synthase kinase-3 inhibition or elevation of cellular Ca²⁺ level

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• 作者：Agnieszka Gizak ; Michal Pirog ; Dariusz Rakus ; ^{drakus@biol.uni.wroc.pl}
• 关键词：FBPase ; Mitochondria ; GSK3 ; Calcium ; Cardiomyocyte ; Hypertrophy
• 刊名：FEBS Letters
• 出版年：2012
• 出版时间：2 January 2012
• 年：2012
• 卷：586
• 期：1
• 页码：13-19
• 全文大小：1464 K

文摘

A growing body of research suggests that fructose 1,6-bisphosphatase (FBPase) might be involved in regulation of cell mortality/survival. However, the precise role of FBPase in the process remains unknown. Here, we show for the first time that in HL-1 cardiomyocytes, inhibition of glycogen synthase kinase-3 results in translocation of FBPase to mitochondria. In vitro experiments demonstrate that FBPase reduces the rate of calcium-induced mitochondrial swelling, affects ATP synthesis and interacts with mitochondrial proteins involved in regulation of volume and energy homeostasis. We suggest that FBPase might be engaged in a regulation of cell survival by influencing mitochondrial function.

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