- 作者：Bolesław Samoliński ; Andrzej Namysłowski ; Filip Raciborski ; filip.raciborski@wum.edu.pl" class="auth_mail" title="E-mail the corresponding author ; Wojciech Zieliński ; Aneta Tomaszewska ; Jacek Borowicz ; Piotr Samel-Kowalik ; Artur Walkiewicz ; Barbara Piekarska ; Agnieszka Lipiec ; Artur Białoszewski ; Edyta Krzych-Fałta
- 关键词：swoiste IgE ; alergia ; astma ; epidemiologia
- 刊名：Alergologia Polska - Polish Journal of Allergology
- 出版年：2016
- 出版时间：July-September 2016
- 年：2016
- 卷：3
- 期：3
- 页码：102-107
- 全文大小：333 K
Aim
The aim of this project was to: a) verify the prevalence of allergies to inhaled allergens; b) determine the role of the most common allergens in allergic rhinitis and asthma.
Methods
The study was based on sera collected in the project ECAP. Individuals in 3 age groups (6–7 years, 13–14 years, 20–44 years) from 9 locations (8 urban and one rural) were included in the study. Specific IgE antibodies concentration was determined, using the reference method CAP, in sera of 4058 respondents. These are antibodies against main allergens responsible for the IgE-dependent allergic diseases (d1 – Dermatophagoides pteronyssinus, g6 – Phleum pratense, m6 – Alternaria alternata, e1 – cat dander).
Results
24.9% of sera revealed the presence of IgE antibody levels in at least class 1 (≥0,35IU/ml) to at least one of the four analyzed allergens (d1, e1, g6, m6). Most frequent were IgE positive test results for house dust mites (d1). The lowest percentage of people with IgE antibodies to at least one of the analyzed allergens was observed in rural area of Zamojszczyzna (20.7%) and in Bialystok (21.3%). The highest percentage of positive IgE test results was achieved in Gdansk (30.7%). In the group of men, 31% have positive IgE test results to at least one of the four analyzed allergens. For women, it was 19.9%. Most frequent IgE antibodies to at least one of the analyzed allergens were observed in the group of 20–24 year old (31.9%). Similar results were obtained in the group of 13–14 years old (29.2%) and 25–29 years old (27.5%). Least frequent IgE antibodies were observed among persons aged 40–44 (17.4%). In the case of positive result of skin prick test (≥9 mm) percentage of subjects with IgE antibodies oscillated from 77.8% to 96.3% depending on the allergen. In the group without asthma, IgE antibody to any analyzed allergen was found in 22.2% of cases. Among those diagnosed with asthma, it was 51.3%. In the group without allergic rhinitis, positive IgE test results for at least one of the tested allergens was obtained in 10.9% of cases. In the group with any form of AR, the percentage was 60.1%.
Conclusion
In the study group most frequently found positive signs of IgE in the order for house dust mite, grass pollen, cat and mold. The effect of test allergens plays an important role in the pathogenesis of AR and asthma.