Synthesis and characterization of the superparamagnetic iron oxide nanoparticles modified with cationic chitosan and coated with silica shell

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• 作者：Joanna Lew ; owska-艁a艅cucka ; Magdalena Staszewska ; Micha艂 Szuwarzy艅ski ; Mariusz K臋pczy艅ski ; Marek Romek ; Waldemar Tokarz ; Agnieszka Szpak ; Gabriela Kania ; Maria Nowakowska
• 关键词：Nanostructed materials ; Oxide materials ; Sol&ndash ; gel process ; Magnetic measurements ; Transmission electron microscopy ; TEM ; X-ray diffraction
• 刊名：Journal of Alloys and Compounds
• 出版年：15 February, 2014
• 年：2014
• 卷：586
• 期：Complete
• 页码：45-51
• 全文大小：1172 K

文摘

Novel method for synthesis of superparamagnetic iron oxide nanoparticles (SPION) modified with a cationic chitosan (CCh) and coated with a silica shell, SPION-CCh-SiO₂ was developed. The process was carried out in two steps. In the first step the chitosan coated SPIONs were obtained by co-precipitation of Fe²⁺ and Fe³⁺ with ammonium hydroxide in aqueous solution of CCh. In the second one, the silica shell is formed on their surfaces. The formation of SPION-CCh-SiO₂ was achieved by direct decomposition of tetraethoxysilane (TEOS) adsorbed on a surface of SPION-CCh dispersed in aqueous phase under sonication and mechanical stirring at room temperature. The chemical composition and physicochemical properties of the materials were determined using X-ray Diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR), Dynamic Light Scattering (DLS) and zeta potential measurements. The morphology of the particles was evaluated by Transmission Electron Microscopy (TEM) and Scanning Electron Microscopy (SEM). Magnetic properties were confirmed using Atomic Force Microscopy/Magnetic Force Microscopy (AFM/MFM) and magnetization measurements. The resulting products are negatively charged, rounded in shape and exhibit the superparamagnetic properties what implies their potential applications in engineering and biomedicine areas.