Involvement of N-methyl-d-aspartate receptors in the antidepressant-like effect of 5-hydroxytryptamine 3 antagonists in mouse forced swimming test and tail suspension test
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- 作者：Nastaran Kordjazy1 ; Arya Haj-Mirzaian1 ; Shayan Amiri ; Sattar Ostadhadi ; Hossein Amini-khoei ; Ahmad Reza Dehpour ; dehpoura@sina.tums.ac.ir" class="auth_mail" title="E-mail the corresponding author ; dehpour@yahoo.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Antidepressant ; 5-HT3 antagonist ; NMDA receptor ; Mice ; Forced swimming test (FST) ; Tail suspension test (TST)
- 刊名：Pharmacology Biochemistry and Behavior
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：141
- 期：Complete
- 页码：1-9
- 全文大小：1455 K
文摘
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5-HT3 antagonists decreased the immobility time of mice in FST and TST.
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NMDA antagonists potentiated the effect of 5-HT3 antagonists in behavioral tests.
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NMDA receptor agonist prevented the anti-immobility effect of 5-HT3 antagonists.
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Antidepressant effect of 5-HT3 antagonists is mediated by NMDA receptor blockade.