2-Bromo-1-(1H-pyrazol-4-yl)ethanone: versatile precursors for novel mono-, bis- and poly{6-(1H-pyrazol-4-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines}

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• 作者：Mostafa E. Salem ; Ahmed F. Darweesh ; Ahmad M. Farag ; Ahmed H.M. Elwahy ; ^{aelwahy@hotmail.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Cyclocondensation ; Alkylation ; Triazolothiadiazine ; Pyrazole
• 刊名：Tetrahedron
• 出版年：2016
• 出版时间：4 February 2016
• 年：2016
• 卷：72
• 期：5
• 页码：712-719
• 全文大小：695 K

文摘

A simple synthesis of novel mono-, bis- and poly{6-(1H-pyrazol-4-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines} is reported. The formation of the target compounds was achieved by the reaction of 2-bromo-1-(5-methyl-1-phenyl-1H-pyrazol-4-yl)ethanone with the appropriate aminotriazolethiol or by the reaction of 6-pyrazolyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine-3-thiol with the appropriate di- and poly(bromo) compounds. The structures of the newly synthesized compounds were established by spectroscopy and elemental analyses.