Evasion of Cell Senescence Leads to Medulloblastoma Progression
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- 作者：Lukas Tamayo-Orrego1 ; 2 ; Chia-Lun Wu1 ; 3 ; Nicolas Bouchard1 ; 3 ; Ahmed Khedher1 ; Shannon M. Swikert1 ; 2 ; Marc Remke4 ; Patryk Skowron5 ; Michael D. Taylor5 ; Fré ; dé ; ric Charron1 ; 2 ; 3 ; 6 ; frederic.charron@ircm.qc.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：medulloblastoma ; sonic hedgehog ; ptch1 ; preneoplasia ; cerebellum ; p53 ; p16ink4a
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：29 March 2016
- 年：2016
- 卷：14
- 期：12
- 页码：2925-2937
- 全文大小：5395 K
文摘
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Medulloblastoma preneoplastic lesions exhibit Ptch1 loss of heterozygosity
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Medulloblastoma preneoplasia display high levels of cell senescence
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Spontaneous p53 mutations or p16ink4a inactivation leads to senescence evasion
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Cell senescence is a tumor-suppressive mechanism for medulloblastoma