Human use of marijuana (
Cannabis sativa) is widel
y assumed
to have rewarding proper
ties, a no
tion suppor
ted b
y i
ts widespread recrea
tional use. However, no s
tud
y has clearl
y demons
tra
ted such effec
ts in animal models. The purpose of
this s
tud
y was
to
tes
t for
the presumed rewarding effec
t of cannabinoids using a condi
tioned place preference paradigm. The resul
ts showed
tha
t animals failed
to develop place condi
tioning a
t a low dose (1.5 mg/kg) and developed a place aversion a
t a high dose (15 mg/kg) of
the ac
tive principle in marijuana,
Δ9-
te
trah
ydrocannabinol (
Δ9-THC), a finding consis
ten
t wi
th mos
t previous s
tudies. Moreover,
the adminis
tra
tion of
the cannabinoid an
tagonis
t SR141716A induced a condi
tioned place preference a
t bo
th a low (0.5 mg/kg) and a high (5 mg/kg) dose. In summar
y, cannabinoid an
tagonism produced place preference while cannabinoid agonism induced place aversion. These resul
ts sugges
t tha
t endogenous cannabinoids serve normall
y to suppress reward or
to induce aversion. t>
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t face=""arial"" size=""-1"" color=""black""> Publisher: t>
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t face=""arial"" size=""-1"" color=""black""> Elsevier Science t>
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t face=""arial"" size=""-1"" color=""black""> Language of Publication: t>
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t face=""arial"" size=""-1"" color=""black""> English t>
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t face=""arial"" size=""-1"" color=""black""> Item Identifier: t>
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t face=""arial"" size=""-1"" color=""black""> S0304-3940(97)13424-3 t>
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t face=""arial"" size=""-1"" color=""black""> Publication Type: t>
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t face=""arial"" size=""-1"" color=""black""> Article t>
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top"">
t face=""arial"" size=""-1"" color=""black""> ISSN: t>
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th=""470"" valign=""
top"">
t face=""arial"" size=""-1"" color=""black""> 0304-3940 t>
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t face=""arial"" size=""-1"" color=""black""> Cited by: t>
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top"">
t face=""arial"" size=""-1"" color=""black""> - Arevalo, Cristina; de Miguel, Rosario; Hernandez-Tristan, Rafael,""Cannabinoid effects on anxiety-related behaviours and hypothalamic neurotransmitters""Pharmacology Biochemistry and Behavior2001pp. 123-131
ttp://202.120.13.78/cgi-bin/sciserv.pl?collection=journals&journal=00913057&issue=v70i0001&article=123_ceoabahn"">Bibliographic Pagettp://202.120.13.78/cgi-bin/sciserv.pl?collection=journals&journal=00913057&issue=v70i0001&article=123_ceoabahn&form=pdf&file=file.pdf"">Full Text - Braida, D.; Pozzi, M.; Cavallini, R.; Sala, M.,""Conditioned place preference induced by the cannabinoid agonist CP 55,940: interaction with the opioid system""Neuroscience2001pp. 923-926
ttp://202.120.13.78/cgi-bin/sciserv.pl?collection=journals&journal=03064522&issue=v104i0004&article=923_cppibt5iwtos"">Bibliographic Pagettp://202.120.13.78/cgi-bin/sciserv.pl?collection=journals&journal=03064522&issue=v104i0004&article=923_cppibt5iwtos&form=pdf&file=file.pdf"">Full Text - Lamarque, S.; Taghzouti, K.; Simon, H.,""Chronic treatment with D9-tetrahydrocannabinol enhances the locomotor response to amphetamine and heroin. Implications for vulnerability to drug addiction""Neuropharmacology2001pp. 118-129
ttp://202.120.13.78/cgi-bin/sciserv.pl?collection=journals&journal=00283908&issue=v41i0001&article=118_ctwetlifvtda"">Bibliographic Pagettp://202.120.13.78/cgi-bin/sciserv.pl?collection=journals&journal=00283908&issue=v41i0001&article=118_ctwetlifvtda&form=pdf&file=file.pdf"">Full Text - Gardner, Eliot L.,""Addictive potential of cannabinoids: the underlying neurobiology""Chemistry and Physics of Lipids2002pp. 267-290
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ttp://202.120.13.78/cgi-bin/sciserv.pl?collection=journals&journal=03010082&issue=v66i0005&article=307_eacrg"">Bibliographic Pagettp://202.120.13.78/cgi-bin/sciserv.pl?collection=journals&journal=03010082&issue=v66i0005&article=307_eacrg&form=pdf&file=file.pdf"">Full Text - Beardsley, Patrick M.; Dance, Mario E.; Balster, Robert L.; Munzar, Patrik,""Evaluation of the reinforcing effects of the cannabinoid CB1 receptor antagonist, SR141716, in rhesus monkeys""European Journal of Pharmacology2002pp. 209-216
ttp://202.120.13.78/cgi-bin/sciserv.pl?collection=journals&journal=00142999&issue=v435i2-3&article=209_eotreorasirm"">Bibliographic Pagettp://202.120.13.78/cgi-bin/sciserv.pl?collection=journals&journal=00142999&issue=v435i2-3&article=209_eotreorasirm&form=pdf&file=file.pdf"">Full Text - Crowley, Thomas J.; Macdonald, Marilyn J.; Whitmore, Elizabeth A.; Mikulich, Susan K.,""Cannabis dependence, withdrawal, and reinforcing effects among adolescents with conduct symptoms and substance use disorderstnote_1"">1""Drug and Alcohol Dependence1998pp. 27-37
ttp://202.120.13.78/cgi-bin/sciserv.pl?collection=journals&journal=03768716&issue=v50i0001&article=27_cdwarecsasud"">Bibliographic Pagettp://202.120.13.78/cgi-bin/sciserv.pl?collection=journals&journal=03768716&issue=v50i0001&article=27_cdwarecsasud&form=pdf&file=file.pdf"">Full Text - Gardner, Eliot L.; Vorel, S. Robert,""Cannabinoid Transmission and Reward-Related Events""Neurobiology of Disease1998pp. 502-533
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t face=""arial"" size=""-1"" color=""black""> Footnotes: tnote_1"">Presented in part at the National Marijuana Conference of the National Institute on Drug Abuse, Washington, D.C., on 20 July 1995.