Endogenous cannabinoids as an aversive or counter-rewarding system in the rat

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• 作者：Sa&ntilde ; udo-Pe&ntilde ; a ; M. Clara ; Tsou ; Kang ; Delay ; Eugene R. ; Hohman ; Andrea G. ; Force ; Michelle ; et. al.
• 关键词：Marijuana ; Cannabinoid ; Δ ; ⁹-Tetrahydrocannabinol ; SR141716A ; Place preference ; Reward ; Aversion
• 刊名：Neuroscience Letters
• 出版年：1997
• 出版时间：February 21, 1997
• 年：1997
• 卷：223
• 期：2
• 页码：125-128
• 全文大小：376 K

文摘

Human use of marijuana (Cannabis sativa) is widely assumed to have rewarding properties, a notion supported by its widespread recreational use. However, no study has clearly demonstrated such effects in animal models. The purpose of this study was to test for the presumed rewarding effect of cannabinoids using a conditioned place preference paradigm. The results showed that animals failed to develop place conditioning at a low dose (1.5 mg/kg) and developed a place aversion at a high dose (15 mg/kg) of the active principle in marijuana, Δ⁹-tetrahydrocannabinol (Δ⁹-THC), a finding consistent with most previous studies. Moreover, the administration of the cannabinoid antagonist SR141716A induced a conditioned place preference at both a low (0.5 mg/kg) and a high (5 mg/kg) dose. In summary, cannabinoid antagonism produced place preference while cannabinoid agonism induced place aversion. These results suggest that endogenous cannabinoids serve normally to suppress reward or to induce aversion. t> td> tr> <tr> <td width=""100"" bgcolor=""#F0F0F0"" valign=""top""> t face=""arial"" size=""-1"" color=""black""> Publisher: t> td> <td width=""470"" valign=""top""> t face=""arial"" size=""-1"" color=""black""> Elsevier Science t> td> tr> <tr> <td width=""100"" bgcolor=""#F0F0F0"" valign=""top""> t face=""arial"" size=""-1"" color=""black""> Language of Publication: t> td> <td width=""470"" valign=""top""> t face=""arial"" size=""-1"" color=""black""> English t> td> tr> <tr> <td width=""100"" bgcolor=""#F0F0F0"" valign=""top""> t face=""arial"" size=""-1"" color=""black""> Item Identifier: t> td> <td width=""470"" valign=""top""> t face=""arial"" size=""-1"" color=""black""> S0304-3940(97)13424-3 t> td> tr> <tr> <td width=""100"" bgcolor=""#F0F0F0"" valign=""top""> t face=""arial"" size=""-1"" color=""black""> Publication Type: t> td> <td width=""470"" valign=""top""> t face=""arial"" size=""-1"" color=""black""> Article t> td> tr> <tr> <td width=""100"" bgcolor=""#F0F0F0"" valign=""top""> t face=""arial"" size=""-1"" color=""black""> ISSN: t> td> <td width=""470"" valign=""top""> t face=""arial"" size=""-1"" color=""black""> 0304-3940 t> td> tr> <tr> <td width=""100"" bgcolor=""#F0F0F0"" valign=""top""> t face=""arial"" size=""-1"" color=""black""> Cited by: t> td> <td width=""470"" valign=""top""> t face=""arial"" size=""-1"" color=""black"">

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t face=""arial"" size=""-1"" color=""black""> Footnotes:

tnote_1"">

1. Presented in part at the National Marijuana Conference of the National Institute on Drug Abuse, Washington, D.C., on 20 July 1995.