Estrogen modulation of calretinin and BDNF expression in midbrain dopaminergic neurons of ovariectomised mice
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- 作者：Hongliang Yia ; b ; Xiaohang Baoc ; Xiaotong Tangd ; Xiaotang Fand ; fanxiaotang2005@163.com" class="auth_mail" title="E-mail the corresponding author ; Haiwei Xue ; haiweixu2001@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Estrogen ; Parkinson ; Calretinin ; BDNF ; pAKT
- 刊名：Journal of Chemical Neuroanatomy
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：77
- 期：Complete
- 页码：60-67
- 全文大小：3230 K
文摘
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Estradiol treatment rescued the dopaminergic neurons loss in the midbrain caused by ovariectomy.
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Estradiol replacement significantly increased DAT and BDNF expression in the midbrain.
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Estradiol reversed the decline of calretinin in the dopaminergic neurons.
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AKT was possibly involved in the neuroprection of estrogen on DA neuron in the midbrain.