Synthesis, characterization, DNA cleavage and in vitro antimicrobial studies of La(III), Th(IV) and VO(IV) complexes with Schiff bases of coumarin derivatives

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• 作者：Ajaykumar Kulkarni ; Sangamesh A. Patil ; Prema S. Badami
• 关键词：Coumarin ; Cyclic voltammetry ; DNA ; Microbial ; Spectral ; Synthesis
• 刊名：European Journal of Medicinal Chemistry
• 出版年：2009
• 出版时间：July 2009
• 年：2009
• 卷：44
• 期：7
• 页码：2904-2912
• 全文大小：641 K

文摘

A series of La(III), Th(IV) and VO(IV) complexes have been synthesized with Schiff bases derived from 8-formyl-7-hydroxy-4-methylcoumarin and o-phenylenediamine/ethylenediamine. The structure of the complexes has been proposed in the light of analytical, spectral (IR, UV–vis, ESR and FAB-mass), Magnetic and thermal studies. The complexes are soluble in DMF and DMSO. The measured molar conductance values indicate that, the complexes are non-electrolytes in nature. The redox behavior of the complexes was investigated by electrochemical method using cyclic voltammetry. The Schiff bases and their complexes have been screened for their antibacterial (Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Salmonella typhi) and antifungal activities (Aspergillus niger, Aspergillus flavus and cladosporium) by Minimum Inhibitory Concentration method. The DNA cleavage activity of La(III) and VO(IV) metal complexes is studied by agarose gel electrophoresis method.