Biological activity of a small molecule indole analog, 1-[(1H-indol-3-yl)methylene]-2-phenylhydrazine (HMPH), in chronic inflammation
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- 作者：Chandra Sekhar Misraa ; Chethan Gejjalagere Honnappaa ; Srinivas Reddy Jittab ; Karthik Gourishettic ; Prasanthi Daramb ; Mahendra Pal Singhd ; Akhila Hosur Shrungeswaraa ; Yogendra Nayakc ; Mazhuvancherry Kesavan Unnikrishnana ; mkunnikrishnan@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Anti-inflammatory ; HMPH [1-((1H-indol-3-yl) methylene)-2-phenylhydrazine] ; Carrageenan ; Lipopolysaccharide ; TNF-α ; Arthritis
- 刊名：Chemico-Biological Interactions
- 出版年：2016
- 出版时间：25 January 2016
- 年：2016
- 卷：244
- 期：Complete
- 页码：71-83
- 全文大小：3427 K
文摘
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HMPH scavenged free radicals and protected the lipid membrane.
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Reduced the LPS-induced ROS/nitrite and TNF-α release in in vitro assays.
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Inhibited MPO, nitrite and leucocyte infiltration in inflammatory rat models.
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Protected bone deformation and reduced acute and chronic inflammation.
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Acts as an immunomodulator and inhibited TNF-α.