Selective synthesis of 4,5-dihydroimidazo- and imidazo[1,5-a]quinoxalines via modified Pictet-Spengler reaction
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- 作者：Akhilesh Kumar Verma ; Rajeev Ranjan Jha ; V. Kasi Sankar ; Raj Pal Singh
- 关键词：VOMUAWMFCXYLQC-UHFFFAOYSA-N ; QZVNULAPUFTIIR-UHFFFAOYSA-N ; HESJLLCGKVDGIB-UHFFFAOYSA-N ; QJTRITOVXCRFIR-UHFFFAOYSA-N ; GXCQDIWNAXPKLQ-UHFFFAOYSA-N ; HVECTIQVQPUSEX-UHFFFAOYSA-N ; BXRFQSNOROATLV-UHFFFAOYSA-N ; BXRFQSNOROATLV-UHFFFAOYSA-N ; YSFBEAASFUWWHU-UHFFFAOY
- 刊名：Tetrahedron Letters
- 出版年：2013
- 出版时间：6 November, 2013
- 年：2013
- 卷：54
- 期：45
- 页码：5984-5990
- 全文大小：3067 K
文摘
An efficient tandem approach for the selective synthesis of 4,5-dihydroimidazo[1,5-a]quinoxalines 6a-g and imidazo[1,5-a]quinoxalines 7a-h by the reaction of 2-imidazolyl anilines 4a-c with aryl aldehydes 5a-k under mild reaction conditions is described. Introduction of electron releasing alkyl groups in substrates 4a-b was found to be instrumental for the success of the reaction.