Quetiapine-induced frequent premature ventricular contraction

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• 作者：Akiko Deguchi ; M.D.¹ ; Masayuki Nakamura ; M.D. ; Ph.D.¹ ; Takehiro Hayashi ; M.D. ; Akira Sano ; M.D. ; Ph.D. ; ^{sano@m3.kufm.kagoshima-u.ac.jp}
• 关键词：Quetiapine ; Side effect ; Sudden death ; Premature ventricular contraction
• 刊名：General Hospital Psychiatry
• 出版年：2012
• 出版时间：March-April, 2012
• 年：2012
• 卷：34
• 期：2
• 页码：211.e1-211.e3
• 全文大小：422 K

文摘

A 17-year-old female diagnosed with bipolar II disorder was treated for emotional lability with quetiapine. Two-lead electrocardiography revealed frequent monomorphic premature ventricular contraction (PVC) during an electroencephalography examination. Twenty-four-hour Holter electrocardiography revealed 0.6 % uniform frequent PVCs and indicated that the readministration and second-time withdrawal of quetiapine markedly increased (7.1 % ) and decreased the frequency of PVC (1.1 % ), respectively. This case indicates that quetiapine can cause PVC as a serious side effect.