Cooperative inputs of Bmp and Fgf signaling induce tail regeneration in urodele amphibians
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- 作者：Aki Makanae ; Kazumasa Mitogawa ; Akira Satoh ; satoha@cc.okayama-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：Limb regeneration ; Tail regeneration ; Amphibian ; FGF ; BMP
- 刊名：Developmental Biology
- 出版年：2016
- 出版时间：1 February 2016
- 年：2016
- 卷：410
- 期：1
- 页码：45-55
- 全文大小：4967 K
文摘
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Similar regulatory mechanisms regulate limb and tail regeneration.
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The spinal cord can transform wound healing into tail regeneration in A. mexicanum.
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Fgf2+Fgf8+Bmp7 can substitute for the spinal cord function in axolotls and newts.
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The blastema cells induced by Fgf2+Fgf8+Bmp7 can differentiate into some cell types.
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Similar experimental results were obtained in a newt.