Global Landscape and Regulatory Principles of DNA Methylation Reprogramming for Germ Cell Specification by Mouse Pluripotent Stem Cells
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- 作者：Kenjiro Shirane1 ; 2 ; Kazuki Kurimoto3 ; 4 ; Yukihiro Yabuta3 ; 4 ; Masashi Yamaji3 ; 4 ; 10 ; Junko Satoh5 ; Shinji Ito5 ; Akira Watanabe6 ; 7 ; Katsuhiko Hayashi3 ; 8 ; 9 ; Mitinori Saitou3 ; 4 ; 6 ; 7 ; saitou@anat2.med.kyoto-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Hiroyuki Sasaki1 ; 11 ; hsasaki@bioreg.kyushu-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 刊名：Developmental Cell
- 出版年：2016
- 出版时间：10 October 2016
- 年：2016
- 卷：39
- 期：1
- 页码：87-103
- 全文大小：4390 K
文摘
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In vitro primordial germ cell specification from mouse ESCs models in vivo process
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PGCLC methylome is derived from progressive dilution of epiblast-like cell methylome
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PRDM14 differentially impacts the hypomethylation in ESCs and PGCLCs
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Female ESCs, but not PGCLCs, create hypomethylated lamina-associated domains