Transgenerational impairment of hippocampal Akt-mTOR signaling and behavioral deficits in the offspring of mice that experience postpartum depression-like illness
刊名:Progress in Neuro-Psychopharmacology and Biological Psychiatry
出版年:2017
出版时间:6 February 2017
年:2017
卷:73
期:Complete
页码:11-18
全文大小:895 K
卷排序:73
文摘
PPD-F1 showed depression-like behaviors and hippocampal Akt-mTOR signaling deficiency at juvenile and adult stages. A single dose of ketamine reversed the behavior deficits and the impairment in Akt-mTOR signaling in PPD-F1. PPD-F2 mice remained deficient in the SP and NSF test and hippocampal Akt-mTOR signaling.