The Intrinsically Disordered Protein Atg13 Mediates Supramolecular Assembly of Autophagy Initiation Complexes
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- 作者：Hayashi Yamamoto1 ; 5 ; 6 ; Yuko Fujioka2 ; 5 ; Sho W. Suzuki1 ; 5 ; 7 ; Daisuke Noshiro3 ; Hironori Suzuki2 ; Chika Kondo-Kakuta1 ; Yayoi Kimura4 ; Hisashi Hirano4 ; Toshio Ando3 ; Nobuo N. Noda2 ; nn@bikaken.or.jp" class="auth_mail" title="E-mail the corresponding author ; Yoshinori Ohsumi1 ; yohsumi@iri.titech.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 刊名：Developmental Cell
- 出版年：2016
- 出版时间：11 July 2016
- 年：2016
- 卷：38
- 期：1
- 页码：86-99
- 全文大小：5155 K
文摘
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An essential autophagy factor Atg13 has a large intrinsically disordered region (IDR)
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The IDR of Atg13 contains two distinct regions binding intermolecularly to Atg17
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Tethering two Atg17 molecules by Atg13 leads to supramolecular Atg1 complex assembly
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The Atg13-mediated supramolecular assembly is responsible for autophagy initiation