Rho-associated protein kinase regulates subcellular localisation of Angiomotin and Hippo-signalling during preimplantation mouse embryo development
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- 作者：Aleksandar I. MihajlovićaAuthor Vitae ; Alexander W. Brucea ; b ; awbruce@prf.jcu.cz" class="auth_mail" title="E-mail the corresponding author
- 关键词：Angiomotin ; Hippo-signalling ; polarization ; preimplantation stage embryo ; Rho-associated protein kinase (Rock)
- 刊名：Reproductive BioMedicine Online
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：33
- 期：3
- 页码：381-390
- 全文大小：2216 K
文摘
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Optimised small chemical Rock-inhibition (RI) in preimplantation mouse embryos.
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RI disrupts tight-junction formation and apical-basolateral intra-cellular polarisation.
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RI causes ectopic outer-cell Hippo-signalling and mis-localised basolaterally enriched Amot
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RNAi confirms Amot as sole mediator of RI derived Hippo-signalling defects
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Rock, via regulating Amot localisation/function, ensures correct cell lineage gene expression