Calcitonin gene-related peptide and calcitonin in the CSF of patients with dementia and depression: Possible disease markers

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• 作者：Math&eacute ; Aleksander A. ; Å ; gren ; Hans ; Wallin ; Anders ; Blennow ; Kaj
• 关键词：Calcitonin ; Calcitonin gene-related peptide ; Cerebrospinal fluid ; Dementia ; Depression ; Neuropeptides ; CSF ; cerebrospinal fluid ; CT ; calcitonin ; CGRP ; calcitonin gene-related peptide ; DOPAC ; 3 ; 4-dihydroxyphenylacetic acid ; DA ; dopamine ; HVA ; homovanillic
• 刊名：Progress in Neuro-Psychopharmacology and Biological Psychiatry
• 出版年：2002
• 出版时间：January, 2002
• 年：2002
• 卷：26
• 期：1
• 页码：41-48
• 全文大小：145 K

文摘

Cerebrospinal fluid (CSF) was obtained from 32 patients with dementia, 19 healthy controls that were age-matched with the dementia patients, and 29 DSM-IV major depression patients and calcitonin gene-related peptide-like immunoreactivity (CGRP-LI) and calcitonin-like immunoreactivity (CT-LI) measured by RIA. CGRP-LI was lower in the dementia group compared to both the controls and depressed patients (P<.01) after covarying out sex and age. CT-LI was decreased in the dementia and depressed patients (P<.05) compared to the controls. A positive relationship between CGRP-LI and CT-LI was found in dementia. A logistic discriminant analysis with calcitonin gene-related peptide (CGRP) and log calcitonin (CT) predicting diagnosis (three classes) revealed a significant overall fit (χ²