A remarkable hematological and molecular response pattern in a patient with polycythemia vera during combination therapy with simvastatin and alendronate

详细信息    查看全文

• 作者：Anders Lindholm Sø ; rensen^a ; ^b ; ^{anderslindholmsorensen@hotmail.com} ; Klaus Kallenbach^c ; Hans Carl Hasselbalch^a
• 关键词：Myeloproliferative neoplasms ; Polycythemia vera ; JAK2-V617F mutation ; Simvastatin ; Alendronate
• 刊名：Leukemia Research Reports
• 出版年：2016
• 出版时间：2016
• 年：2016
• 卷：6
• 期：Complete
• 页码：20-23
• 全文大小：1091 K
• 卷排序：6

文摘

We report a 57-year old man with polycythemia vera, who had a remarkable hematological and molecular response during treatment with simvastatin and alendronate. The patient was treated with this combination for 56 months, and during this period the patient has been in complete hematological remission. The JAK2-V617F allele burden has dropped from 64% to sustained values below 20%, and follow-up bone marrow biopsies have revealed no change in PV features, without any regular cytoreductive treatment.