Bacterial strain-independent AUC/MIC and strain-specific dose–response relationships reflecting comparative fluoroquinolone anti-pseudomonal pharmacodynamics in an in vitro dynamic model

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• 作者：Lubenko ; Irene Yu ; Vostrov ; Sergey N. ; Portnoy ; Yury A. ; Zinner ; Stephen H. ; Firsov ; Alexander A.
• 关键词：Fluoroquinolones ; Pharmacodynamics ; In vitro model
• 刊名：International Journal of Antimicrobial Agents
• 出版年：2002
• 出版时间：July, 2002
• 年：2002
• 卷：20
• 期：1
• 页码：44-49
• 全文大小：219 K

文摘

To compare the antimicrobial effects (AMEs) of two quinolones in terms of the AUC/MIC- and dose (D)–response relationships, five differentially susceptible clinical isolates of Pseudomonas aeruginosa were exposed to decreasing concentrations of ciprofloxacin (two 12-h doses with T_1/2