Selective in vitro and in silico butyrylcholinesterase inhibitory activity of diterpenes and rosmarinic acid isolated from Perovskia atriplicifolia Benth. and Salvia glutinosa L.

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• 作者：F. Sezer Senol^a ; Sylwester Ślusarczyk^b ; ^c ; Adam Matkowski^b ; Alfonso P&eacute ; rez-Garrido^c ; Francisco Giró ; n-Rodrí ; guez^d ; Jos&eacute ; P. Ceró ; n-Carrasco^c ; Helena den-Haan^c ; Jorge Peñ ; a-Garcí ; a^c ; Horacio P&eacute ; rez-Sá ; nchez^c ; ^{hperez@ucam.edu} ; Krzysztof Domaradzki^e ; Ilkay Erdogan Orhan^a ; ^{iorhan@gazi.edu.tr}
• 关键词：Perovskia atriplicifolia (Lamiaceae) ; Salvia glutinosa (Lamiaceae) ; Tanshinones ; Diterpenes ; Cholinesterase inhibition ; Butyrylcholinesterase ; QSAR ; Molecular modeling
• 刊名：Phytochemistry
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：133
• 期：Complete
• 页码：33-44
• 全文大小：1725 K
• 卷排序：133

文摘

Diterpenes and rosmarinic acid were tested against cholinesterase enzymes. QSAR and molecular docking studies have been also performed on the active compounds. All of the compounds showed higher or closer inhibition against BChE. In silico data well-matched with the in vitro outcomes of the present study. 15,16-Dihydrotanshinone is promising due to its dual inhibition toward both enzymes.