- 作者：Carlo ; Alessandria ; ; ; carloalessandria@libero.it ; Chiara ; Elia ; Lavinia ; Mezzabotta ; Alessandro ; Risso ; Alida ; Andrealli ; Maurizio ; Spandre ; Anna ; Morgando ; Alfredo ; Marzano ; Mario ; Rizzetto
- 关键词：Albumin ; Ascites ; Circulatory dysfunction ; Cirrhosis ; Paracentesis
- 刊名：Digestive and Liver Disease
- 出版年：2011
- 出版时间：November 2011
- 年：2011
- 卷：43
- 期：11
- 页码：881-886
- 全文大小：427 K
Background
Paracentesis-induced circulatory dysfunction is a well-known complication of large volume paracentesis. Albumin infusion (8 g of albumin/L of ascites removed) is effective in preventing it, but high costs and scant availability limit its use.Aim
To compare standard vs half albumin doses.
Methods
Seventy cirrhotic patients treated with large volume paracentesis were randomized to receive intravenous albumin as prevention of paracentesis-induced circulatory dysfunction: group 1 (35 patients) received 4 g/L of ascites removed, group 2 (35 patients) received 8 g/L of ascites removed.
Results
The incidence of paracentesis-induced circulatory dysfunction (14 % vs 20 % in group 1 and group 2, respectively; p = ns), hyponatremia (9 % vs 6 % , p = ns) and renal impairment (0 % in both groups) on the 6th day from paracentesis was similar between the two groups. After 6 months of follow-up, rates of survival and of recurrence of ascites requiring large volume paracentesis were not different between the two groups.
Conclusions
This unblinded, randomized, pilot study suggests that treatment with half doses of albumin is effective in the prevention of paracentesis-induced circulatory dysfunction and its related clinical complications in cirrhotic patients with tense ascites treated by large volume paracentesis. If confirmed, these results could support a significant costs reduction in the management of ascites in cirrhotic patients.