Appropriate ICD therapies in CA patients are common (27% of the patients), regardless of CA and prevention types
Conventional selection criteria for ICD implantation in primary prevention (e.g. LVEF) are not suitable for CA patients.
Patients with an advanced form of CA, particularly the AL-CA type, had a very poor outcome despite ICD placement.
TTR-CA with early cardiac involvement and AL-CA awaiting cardiac transplant should be patients considered for an ICD.
Prospective studies are warranted to further investigate whether prophylactic ICD implantation would reduce mortality in CA.