Sleep Disorders in Patients on a Kidney Transplant Waiting List

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• 作者：Bernabé ; Jurado Gá ; mez ; Alej ; ro Martí ; n-Malo ; Mari Carmen Ferná ; ndez Marí ; n ; Alberto Rodrí ; guez-Benot ; Natalia Pascual ; Luis Muñ ; oz Cabrera ; Pedro Aljama
• 关键词：Apnea-hypopnea index ; Oxygen desaturation index ; Chronic renal failure ; Kidney transplantation ; Sleep disorders ; Sleep-disordered breathing
• 刊名：Archivos de Bronconeumología (English Edition)
• 出版年：2008
• 出版时间：2008
• 年：2008
• 卷：44
• 期：7
• 页码：371-375
• 全文大小：75 K

文摘

Objective

To evaluate the prevalence of sleep disorders in patients awaiting kidney transplants compared to a control group.

Patients and methods

We carried out an observational study of 23 patients on a kidney transplant waiting list in comparison with 20 healthy volunteers matched for age, sex, and body mass index (BMI). Overnight polysomnography was performed and a diagnosis of sleep apnea-hypopnea syndrome (SAHS) established when the apnea-hypopnea index (AHI) was 10 or higher.

Results

Eighty-two percent of the patients awaiting kidney transplants (16 men and 7 women with a mean [SD] age of 51 [15] years and a mean BMI of 25 [3.8] kg/m²) had some type of sleep disorder. The most frequent disorders were SAHS (48 % ) and insomnia and periodic limb movement disorder (30 % ). Patients showed poorer sleep efficiency compared to the control group (75.4 % vs 87.8 % ; P=.01) and a lower percentage of slow-wave and rapid eye movement sleep (24.5 % vs 40 % ; P=.001). Those with sleep-disordered breathing had a higher AHI (17.7 vs 3.6; P=.00l) and oxygen desaturation index (31.5 compared to 8.2; P=.00l).

Conclusions

Sleep disorders are common in patients awaiting kidney transplants. Such patients show reduced quantity and quality of sleep compared to controls and a significantly elevated number of respiratory events that may affect morbidity and mortality.