Synthesis of a Mexican Bean Beetle Azamacrolide Allomone via a Novel Lactam to Lactone Ring Expansion

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• 作者：Gribble ; Gordon W. ; Silva ; Richard A.
• 刊名：Tetrahedron Letters
• 出版年：1996
• 出版时间：March 25, 1996
• 年：1996
• 卷：37
• 期：13
• 页码：2145-2148
• 全文大小：179 K

文摘

The Mexican bean beetle (Epilachna varivestis) defensive secretion azamacrolide 1 has been synthesized via the novel ring expansion of N-hydroxyethyl lactam 12, which was prepared in seven steps from cyclooctanone (6).