Calorimetric and spectroscopic investigations of the binding of metallated porphyrins to G-quadruplex DNA
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- 作者：Jesse I. DuPont ; Kate L. Henderson ; Amanda Metz ; Vu H. Le ; Joseph P. Emerson ; Edwin A. Lewis
- 关键词：Isothermal titration calorimetry ; G-quadruplex ; Telomere ; hTel22 ; TMPyP4 ; Thermodynamics
- 刊名：Biochimica et Biophysica Acta (BBA) - General Subjects
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：1860
- 期：5
- 页码：902-909
- 全文大小：906 K
文摘
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apo-TMPyP4, Ni(II)-TMPyP4, and Cu(II)-TMPyP4 bind tightly to hTel22 G-quadruplex.
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Co(III)-TMPyP4 and Zn(II)-TMPyP4 bind poorly to hTel22 G-quadruplex.
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The metal center coordination geometry strongly influences the binding energetics.