Infratentorial gray matter atrophy and excess in primary craniocervical dystonia

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• 作者：Camila C. Piccinin ; Maria C.A. Santos ; Luiza G. Piovesana ; Lidiane S. Campos ; Rachel P. Guimar茫es ; Brunno M. Campos ; Fabio R. Torres ; Marcondes C. Fran莽a ; Augusto C. Amato-Filho ; Iscia Lopes-Cendes ; Fern ; o Cendes ; Anelyssa D'Abreu
• 关键词：Craniocervical dystonia ; Infratentorial ; Cerebellum ; Voxel based morphometry ; SUIT tool
• 刊名：Parkinsonism and Related Disorders
• 出版年：February, 2014
• 年：2014
• 卷：20
• 期：2
• 页码：198-203
• 全文大小：481 K

文摘

Background

Primary craniocervical dystonia (CCD) is generally attributed to functional abnormalities in the cortico-striato-pallido-thalamocortical loops, but cerebellar pathways have also been implicated in neuroimaging studies. Hence, our purpose was to perform a volumetric evaluation of the infratentorial structures in CCD.

Methods

We compared 35 DYT1/DYT6 negative patients with CCD and 35 healthy controls. Cerebellar volume was evaluated using manual volumetry (DISPLAY software) and infratentorial volume by voxel based morphometry of gray matter (GM) segments derived from T1 weighted 3聽T MRI using the SUIT tool (SPM8/Dartel). We used t-tests to compare infratentorial volumes between groups.

Results

Cerebellar volume was (1.14聽卤聽0.17)聽脳聽10²聽cm³ for controls and (1.13聽卤聽0.14)聽脳聽10²聽cm³ for patients; p聽=聽0.74. VBM demonstrated GM increase in the left I-IV cerebellar lobules and GM decrease in the left lobules VI and Crus I and in the right lobules VI, Crus I and VIIIb. In a secondary analysis, VBM demonstrated GM increase also in the brainstem, mostly in the pons.

Conclusion

While gray matter increase is observed in the anterior lobe of the cerebellum and in the brainstem, the atrophy is concentrated in the posterior lobe of the cerebellum, demonstrating a differential pattern of infratentorial involvement in CCD. This study shows subtle structural abnormalities of the cerebellum and brainstem in primary CCD.