Synthesis and characterization of a novel semi-IPN hydrogel based on Salecan and poly(N,N-dimethylacrylamide-co-2-hydroxyethyl methacrylate)

详细信息    查看全文

• 作者：Xinyu Hu ; Liandong Feng ; Wei Wei ; Aming Xie ; Shiming Wang ; Jianfa Zhang ; Wei Dong ; ^{dongwei@njust.edu.cn" class="auth_mail}
• 关键词：Salecan ; Poly(DMAA-co-HEMA) ; Semi-IPN hydrogels ; Porous structure ; Robust materials
• 刊名：Carbohydrate Polymers
• 出版年：25 May, 2014
• 年：2014
• 卷：105
• 期：Complete
• 页码：135-144
• 全文大小：2993 K

文摘

Salecan is a novel water-soluble, high molecular mass extracellular 尾-glucan produced by Agrobacterium sp. ZX09. Salecan has excellent physicochemical and biological properties, making it very suitable for hydrogel preparation. In this study, a series of novel semi-interpenetrating polymer network (semi-IPN) hydrogels containing Salecan and poly(N,N-dimethylacrylamide-co-2-hydroxyethylmethacrylate) (poly(DMAA-co-HEMA)) were synthesized by radical polymerization and semi-IPN technology. Structure and morphology of the hydrogels were characterized by FTIR, XRD, TGA and SEM. The semi-IPNs had a well-interconnected porous structure with tunable pore size ranging from 6 to 41 渭m. Swelling capability of the hydrogels was improved by introducing the hydrophilic Salecan. Rheological results indicated that the incorporation of poly(DMAA-co-HEMA) into hydrogels enhanced the storage modulus. Compression tests revealed that these semi-IPNs were robust materials with compressive modulus between 13.3 and 90.5 kPa, the addition of Salecan increased the fracture strain from 71.1% to 88.8%. Degradation and cytotoxicity tests demonstrated that semi-IPNs were degradable and non-toxic.