The dual role of cathelicidins in systemic inflammation

详细信息    查看全文

• 作者：Fabiano Pinheiro da Silva ; ^{pinheirofabiano@hotmail.com} ; Marcel Cerqueira Cé ; sar Machado
• 关键词：CRAMP ; cathelin related antimicrobial peptide ; AMPs ; antimicrobial peptides
• 刊名：Immunology Letters
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：182
• 期：Complete
• 页码：57-60
• 全文大小：543 K
• 卷排序：182

文摘

Antimicrobial peptides are key components of the innate immune system. Cathelicidins are a class of antimicrobial peptide found in humans, mice, and rats, among others. The role of cathelicidins is somewhat confounding, as they exhibit both pro-and anti-inflammatory activity. Studies have shown that LL-37 is recognized by multiple receptors. This letter reviews what is currently known about the dual activity of cathelicidins in systemic diseases.